Manufacturer: Berlin-Chemie, Germany
Substance: Levothyroxine Sodium
Pack: 100 tabs (100 mcg/tab)
Weight Loss With Levothyroxine Medication
L-Thyroxin. Levothyroxine is a synthetic thyroid hormone prescribed to treat low thyroid function, also known as hypothyroidism. Part of your endocrine system, your thyroid gland is located at the base of your throat and creates the hormones that control how quickly you use both oxygen and energy — the basis of your metabolism. A sluggish thyroid doesn’t produce enough hormones; as a result your metabolism slows down — which can easily lead to weight gain. Once you begin to take levothyroxine, your metabolism will normalize and weight loss should be easier.
Metabolism and Weight Loss
Weight loss with hypothyroidism can be challenging because a slower metabolism results in fewer calories being used. Taking levothyroxine should boost your metabolism, helping you to burn more calories, even at rest. You can also keep your metabolism high by burning more calories through exercise — especially strength training exercises, which build muscle mass. The American College of Sports Medicine notes that increasing your ratio of muscle to fat will enable you to burn more calories, even at rest. Consume at least 18 percent to 20 percent of your calories from lean protein, suggests the ACSM.
Dietary Guidelines — Carbohydrates
There is no single diet for weight-loss with hypothyroidism, explains the Mayo Clinic. The best diet for you is the one you can actually stay on — and should include eating a variety of healthy foods, calorie reduction, portion control and exercise. The Thyroid Information Network says that when your metabolism is slowed down, so is your body’s ability to process sugar, leading to higher glucose and insulin levels. Simple carbohydrates such as sugar and starches should be limited. You don’t need to follow a low-carb diet — unless that lifestyle works for you — but choosing complex carbs or using the glycemic index to help choose carbs that have a minimal effect on glucose will help you lose weight on levothyroxine.
Calories, Weight Loss and Metabolism
How much food you eat is as important as the types of food you eat. The more you restrict calories, the faster you’ll lose weight — but only if you still consume enough calories to support basic metabolic function. The National Institutes of Health says that you need between 1,200 and 15,00 calories daily to ensure proper metabolic function. When you don’t eat enough calories, your metabolism slows down, going into “starvation mode” and conserving energy for survival. With hypothyroidism your metabolism is already slow — slowing it further by not eating enough, or by waiting too long between eating, will only hinder weight loss. Try to eat at least every four hours to keep your metabolism high.
Levothyroxine Interactions and Iodine
Iodine is an essential element for making thyroid hormone, but iodine deficiency rarely causes hypothyroidism. If you’re taking levothyroxine, you’re thyroid isn’t manufacturing thyroid hormone — levothyroxine is providing an already fully formed synthetic hormone replacement. But it is important that nothing in your diet interferes with the absorption of your medication. Levothyroxine should be taken by itself on an empty stomach. Vitamins that contain calcium and iron can block the absorption of levothyroxine, as can antacids that contain aluminum hydroxide. Don’t rely on diet pills to lose weight. Orlistat, the active ingredient in Alli, can also stop your body from assimilating thyroid hormone replacement. Anything that can interfere with your levothyroxine medication should be taken two to four hours after you take levothyroxine .
How is Thyroxine Used for Weight Loss?
Thyroxine or T4 is a hormone made by your thyroid. L-thyroxine, also known as levothyroxine, is a synthetic T4 thyroid replacement hormone. The generic name for this medication is levothyroxine and it’s sold under the brand names Sythroid, Levoxyl, Unithroid or Tirosint. Levothyroxine is the most common drug used to treat hypothyroidism — an underactive thyroid. Because your thyroid produces the hormones that control metabolism, hypothyroidism can often cause weight gain. Taking levothyroxine will replace needed hormones and boost metabolism, which may lead to weight loss.
Your thyroid gland produces T3 and T4 hormones, which control the rate at which your body burns calories and oxygen — that is, your metabolic rate. When your thyroid slows hormone production, your metabolism slows; so does your heart rate and other functions. You may feel tired, weak and sensitive to cold and you may gain weight. The most common treatment for hypothyroidism is a replacement hormone supplement — levothyroxine. Once you have the correct balance of thyroid hormone, your metabolism will right itself and you will have an easier time losing weight.
If your metabolism slows down, you burn fewer calories, even at rest. If you continue eating the same amount of food, you will start to gain weight. According to the American Thyroid Association, the more severe the hypothyroidism, the greater the weight gain. However, it’s not always fat gain; the ATA says that 5 to 10 lbs. of the weight that hypothyroid patients gain is an accumulation of excess salt and water. Once hypothyroidism is controlled by taking L-thyroxine you could expect to lose some weight — but no more than 10 percent of your current body weight.
More than just an underactive thyroid may cause significant weight gain. Once your hypothyroidism is corrected — it can take several weeks for L-thyroxine to work — your metabolism will be back to normal. Once your metabolism is stable, you will be able to gain or lose weight like anyone without thyroid issues. Taking a higher dose of L-thyroxine to speed weight loss can have serious medical consequences and is not recommended.
Excessive use of L-thyroxine can speed your metabolism and lead to weight loss — and serious health problems, including an irregular heartbeat, angina, heart attack and a loss of bone mass — in severe cases it can lead to osteoporosis. Abusing your prescription medication in this way can lead to factitious hyperthyroidism, an overactive thyroid. It may take between 2 and 4 weeks after you lower your dosage for symptoms to disappear.
What is L-Thyroxin Berlin-Chemie?
L-Thyroxin Berlin-Chemie is a replacement for a hormone normally produced by your thyroid gland to regulate the body’s energy and metabolism.
L-Thyroxin Berlin-Chemie is given when the thyroid does not produce enough of this hormone on its own. L-Thyroxin Berlin-Chemie treats hypothyroidism (low thyroid hormone).
L-Thyroxin Berlin-Chemie is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer.
L-Thyroxin Berlin-Chemie may also be used for purposes not listed in L-Thyroxin Berlin-Chemie guide. Overdose symptoms may include headache, leg cramps, tremors, feeling nervous or irritable, chest pain, shortness of breath, and fast or pounding heartbeats.
What should I avoid while taking L-Thyroxin Berlin-Chemie?
Certain medicines can make L-Thyroxin Berlin-Chemie less effective if taken at the same time. If you use any of the following drugs, avoid taking them within 4 hours before or 4 hours after you take L-Thyroxin Berlin-Chemie:
calcium carbonate (Alka-Mints, Calcium Oyster Shell, Caltrate, Os-Cal, Oyster Shell Calcium, Rolaids Soft Chew, Tums, and others);
ferrous sulfate iron supplement;
sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex); or
antacids that contain aluminum or magnesium–Acid Gone, Gaviscon, Maalox, Milk of Magnesia, Mintox, Mylanta, Pepcid Complete, and others).
Avoid the following food products, which can make your body absorb less L-Thyroxin Berlin-Chemie: infant soy formula, cotton seed meal, walnuts, and high-fiber foods.
L-Thyroxin Berlin-Chemie side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
fast or irregular heart rate;
fever, hot flashes, sweating;
sleep problems (insomnia);
changes in your menstrual periods; or
vomiting, diarrhea, appetite changes, weight changes.
Common side effects may include mild hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect L-Thyroxin Berlin-Chemie?
Many other medicines can be affected by your thyroid hormone levels. Other medicine may also increase or decrease the effects of L-Thyroxin Berlin-Chemie.
Many drugs can interact with L-Thyroxin Berlin-Chemie and not all possible interactions are listed in L-Thyroxin Berlin-Chemie guide.
Tell your doctor about all medications you use, start using, or stop using during your treatment with L-Thyroxin Berlin-Chemie. This includes prescription, over-the-counter, vitamin, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Levothyroxine sodium is an excellent fat burner since your metabolism is greatly increased while being on it. You can afford to be a little sloppier on precontest dieting since it will still burn fat when you are taking in a lot of calories since your metabolism is going haywire.
T4( L-Thyroxin 100) is a synthetic thyroid hormone (Type T-4). This product usually comes in bottles of 100 tablets at 100 mcgs each. It is available in a variety of doses though ranging from 5 – 100 mcgs. per tablet.
Bodybuilders love this product for many reasons. This product is an excellent fat burner since your metabolism is greatly increased while being on it. You can afford to be a little sloppier on precontest dieting since it will still burn fat when you are taking in a lot of calories since your metabolism is going haywire. Step over Ripped Fuel, E/C/A stack, Thermodrine.
When taken with clenbuterol, this is the single best fatburning combination that is available today (with the possible exception of DNP). It also helps to make steroids more effective since it is such a good aid for protein synthesis. Most people need to be careful to start with a low dosage, about 50 mcgs. per day and increase by about one tab or 50 mcgs per day every 5-6 days. Make sure that you don’t go over 100-200 mcgs. per day at the very most. On days that you take muliple tabs, divide the tabs evenly across the day (i.e. 200 mcgs. would be 4 doses of 50 mcgs. apiece spread evenly across the day.) You also need to make sure that you cycle down off this product as well to keep the thyroid functioning properly as well. Don’t take for more than 5 weeks at a time as well. After doing a cycle of this drug, make sure you go at least 8 weeks before doing it again as to allow normal thyroid functioning to return.
Synthetic thyroid hormone
Thyroid, complementary deficiency of thyroid hormones.
After partial conversion to liothyronine (in liver and kidney) and move into the cells of the body influences the development and growth of tissue metabolism. In small doses it has anabolic effects on protein and fat metabolism. In average doses stimulates the growth and elaboration, increase tissue oxygen demand, stimulates the metabolism of proteins, fats and carbohydrates, increases the functional activity of the cardiovascular system and CNS. In high doses, it inhibits the production of thyrotropin-releasing hormone of the hypothalamus and pituitary TSH.
The therapeutic effect is observed after 7-12 days, during the same time still apply after drug withdrawal. Clinical effect with hypothyroidism manifests itself in 3-5 days. Diffuse goiter decreases or disappears within 3-6 months.
When ingestion levothyroxine is absorbed almost exclusively in the upper part small intestine. Absorbed up to 80% of the dose of the drug. Food intake reduces the absorption of levothyroxine. Cmax in serum is attained at 6 hours after administration. After absorption of more than 99% of the drug bound to serum proteins. In various tissues occurs monodeyodirovanie of levothyroxine with the formation of triiodothyronine and inactive ingredients. Thyroid hormones are metabolized mainly in the liver, kidneys, brain and muscles. A small amount of the drug undergoes deamination and decarboxylation as well as conjugation with sulfuric acid and glucuronic acid (in the liver). The metabolites are excreted in the urine and bile. T1 / 2 – 6-8 days.
Hypothyroidism of any origin: primary and secondary hypothyroidism after surgery for Struma, as a result of treatment with radioactive iodine (as replacement therapy).
Prevention of relapse (re-formation) nodular goiter after surgery for goiter with normal thyroid function.
Diffuse goiter with normal function.
In combination therapy in the treatment of hyperthyroidism tireostatikami after reaching the its normal function.
Thyroid tumors, preferably after surgery for the purpose of suppression of tumor recurrence and as replacement therapy
Increased individual sensitivity to the drug, acute myocardial infarction, untreated adrenal insufficiency, hyperthyroidism.
In diseases of the cardiovascular system – coronary artery disease (atherosclerosis, angina, myocardial infarction), hypertension, arrhythmias; diabetes mellitus; severe long-existing hypothyroidism; malabsorption syndrome (possible dose adjustment).
Pregnancy and breast-feeding:
During pregnancy and breastfeeding should continue treatment. Use of the drug during pregnancy in combination with tireostatikami contraindicated. Since tireostatiki unlike of levothyroxine can pass through the placenta, the fetus may develop hypothyroidism.
Allergic reactions (skin rashes, itching of the skin). When used in excessive doses – hyperthyroidism (change in appetite, dysmenorrhea, chest pain, diarrhea, tachycardia, arrhythmia, fever, tremor, headache, irritability, muscle cramps of the lower extremities, nervousness, sweating, difficulty sleeping, vomiting, weight loss body). When used in insufficiently effective doses – hypothyroidism (dysmenorrhea, constipation, dry, puffy skin, headache, fatigue, myalgia, drowsiness, weakness, lethargy, weight gain).
Levothyroxine increases the effect of indirect anticoagulants (may decrease their doses). With simultaneous use of cholestyramine reduces the plasma concentration of of levothyroxine by its inhibition of absorption in the intestine. Quick in / with the introduction of phenytoin increases the concentration not connected with the plasma proteins of levothyroxine and liothyronine. Salicylates, dicoumarol, furosemide in high doses (250 mg) enhance the effect of of levothyroxine because can displace it from the binding sites to plasma proteins.
Dosing and Administration:
Inside, on an empty stomach, at least 30 minutes before breakfast. The daily dose is established and controlled individually on the basis of laboratory and clinical survey data.
As experience shows, with a small body weight and the presence of a large nodular struma enough low dose.
Unless otherwise prescribed, the following dosage recommendations:
At thyroid gland hypofunction initial daily dose for adults – 25-100 mcg, then increase the dose prescribed by a doctor every 2-4 weeks at 25-50 mcg until the maintenance daily dose – 125-250 mcg; children – 12.5-50 mcg, at prolonged course of treatment dose is determined by weight and height of the child (of approximate calculation of 100 to 150 mcg of levothyroxine sodium per 1 m2 of body surface);
for the prevention of recurrence of goiter and diffuse goiter adults – 75-200 mcg / day;
consisting of combined therapy for the treatment of hyperthyroidism tireostatikami – 50-100 mcg / day;
in the treatment malignant tumor daily dose – 150-300 mcg.
Estimated maintenance daily dose of levothyroxine sodium:
|Age||Dose with goiter, mcg / kg / day||Dose with hypothyroidism, mcg / kg / day|
|Infants 1/4 years||25-37,5||25|
|Infants 1/2 years||25-37,5||37,5|
|Young children, 1 year||25-37,5||37,5|
|Young children, 5 year||25-62,5||60|
|School-age children, 7 years||50-100||75-100|
|School-age children, 12 years||100-150||100|
The daily dose is determined individually depending on indications.
During pregnancy increases the need for thyroid hormones, so it is necessary to inform the doctor about an existing or ensuing pregnancy during treatment, so that, if necessary, could be to adjust the dose of the drug.
Symptoms: thyrotoxic crisis, sometimes delayed for several days after ingestion.
Treatment: the appointment of beta-blockers, intravenous administration of corticosteroids, plasmapheresis.
The appointment of other drugs containing iodine, necessary to consult a doctor. It is recommended to periodically determine the content of TSH in the blood, increased level of which indicates a lack of dose. The adequacy of thyroid suppressive therapy is evaluated as to suppress the capture of radioactive iodine. With long-existing multinodular goiter before treatment should be conducted stimulus test with thyrotropin-releasing hormone. In most cases, hypothyroidism, metabolic status should be restored gradually, especially in elderly patients and patients with disorders of the cardiovascular system. For elderly patients the initial dose should not exceed 50 mcg. When applied in the II and III trimester usually increase the dose by 25%.
With caution is prescribed for severe long-existing thyroid gland hypo function. Before treatment should eliminate the possibility of pituitary or hypothalamic hypothyroidism.
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